While collecting relics in Moonlighter 2: The Endless Vault, you will feel the need for more potions. Potions are a crucial item for those who want to survive longer.

There are a total of 4 potion upgrades you can do to maximize your chances of survival. If you get lucky, you might get one from the bonus pedals. But let’s not rely on luck and take a look at how you can unlock more potions in Moonlighter 2: The Endless Vault.

How to Unlock and Upgrade Potions in Moonlighter 2

As I mentioned above, there are a total of 4 potion upgrades you can do in Moonlighter 2: The Endless Vault. Each upgrade will require some effort to unlock. Aside from an extra potion, you will also get some buffs.

Arcanism Upgrades cost Gold and crafting materials (primarily Slime Shards from slimes, plus rares like Sun Eater, Echo Link, etc., dropped by enemies/breakables/bosses).

Prioritize Extra Potion upgrades first for more uses, then Max Health and Potion Healing (+5 health per potion per upgrade). All are permanent, no respec.

Tier 1 Upgrades (After Kalina Run 1)

UpgradeCostEffect
Extra Potion2,000 Gold + 5 Slime Shards+1 potion use (total: 2) progameguides.com
Potion Healing5,000 Gold + 10 Slime ShardsPotions heal +5 more health
Potion Healing (2)8,000 Gold + 15 Slime ShardsPotions heal +5 more health
Max. Health2,000 Gold + 10 Slime Shards+10 max health
Max. Health (2)5,000 Gold + 15 Slime Shards+10 max health
Onsen Room5,000 Gold + 4 Sun EaterSpawns healing onsen before Boss room thegamer.com
Initial Perk8,000 Gold + 6 Echo LinkPerk pedestal at dungeon start

Tier 2 Upgrades (After Endless Vault Level 2 / 50k Gold)

UpgradeCostEffect
Extra Potion (2)5,000 Gold + 15 Slime Shards+1 potion use (total: 3)
Potion Healing (3)8,000 Gold + 20 Slime ShardsPotions heal +5 more health
Potion Healing (4)12,000 Gold + 25 Slime ShardsPotions heal +5 more health
Max. Health (3)5,000 Gold + 20 Slime Shards+10 max health
Max. Health (4)8,000 Gold + 25 Slime Shards+10 max health
Potion Room8,000 Gold + 6 Oneiric QuartzUnlocks dungeon rooms that grant potions thegamer.com
Onsen Healing12,000 Gold + 8 Moon FlowerOnsons heal +100% more

Tier 3 Upgrades (After Endless Vault Level 4 / 200k Gold)

UpgradeCostEffect
Extra Potion (3)8,000 Gold + 25 Slime Shards+1 potion use (total: 4)
Potion Healing (5)12,000 Gold + 30 Slime ShardsPotions heal +5 more health
Potion Healing (6)16,000 Gold + 35 Slime ShardsPotions heal +5 more health
Max. Health (5)8,000 Gold + 30 Slime Shards+10 max health
Max. Health (6)12,000 Gold + 35 Slime Shards+10 max health
Miniboss Potion12,000 Gold + 8 Echo BondPotion drop after miniboss
Health Restore16,000 Gold + 10 Oneiric StoneRestore 5 health on room entry

With these upgrades alone, you will have a total of 5 potions. If you are looking for more potions, I suggest you go and explore dungeons.

You will also require a ton of Gold and Slime Shards for the upgrades. Gold can be obtained by selling relics, and Slime Shards drop from pink blobs in the Kalina map. After that, just talk to Eris to get your desired upgrades.

That’s all for this Moonlighter 2: The Vault guide on how to get more potions. If you are struggling with other aspects of the game, then feel free to check out other guides on that.